#MaleHypofertility, #Homocysteine, #MTHFRSNP, #5MTHF, #OneCarbonCycle, #Folates
Clement 2023 – 5MTHF supplementation for HHcy
“Hyperhomocysteinemia in hypofertile male patients can be alleviated by supplementation with 5MTHF associated with one carbon cycle support”
Authors: A. Clement, E. Amar, P. Clement, É. Sedbon, C. Brami, S. Alvarez and Y. Menezo
Capsule: Homocysteine is known to be detrimental also to male infertility and a high rate of infertile male has high homocysteine. A large group of infertile males were tested for homocysteine before and after supplementation with Impryl. As seen in PCOS women (See Schiuma 2020) also in infertile men Impryl decreased homocysteine in all the treated patients, including those starting with a normal value. Many of the patients conceived after the treatment. Homocysteine testing and treatment is worth to consider in men suffering from infertility.
#Homocysteine, #PCOS, #FollicularFluid, #BlastocystRate, #Micronutrients
Kucuk 2023 – Follicular HCY in PCOS
“Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients”
Authors: T. Kucuk, P. E. Horozal, A. Karakulak, E. Timucin and M. Dattilo
Capsule: Homocysteine is detrimental for fertility and some studies had shown that the amount of homocysteine in follicular fluids could be directly involved. Impryl had been already shown to decrease blood homocysteine in all treated women, thus it was investigated whether Impryl decreases homocysteine also in follicular fluid and whether this associate to pregnancies. PCOS ladies undergoing an ART cycle were tested for follicular homocysteine after Impryl for 3 months or no treatment. Follicular homocysteine was directly related to the pregnancies and its decrease with Impryl marked an improved clinical outcome. This is the first time a supplementation improves the clinical outcomes in ART cycles.
#Cysteine, #HydrogenSulfide, #LC-MS/MS, #L-Cystine, #Micronutrients, #Pyridoxal 5-Phosphate
Dattilo 2022 – Modulation of human H2S metabolism
“Modulation of Human Hydrogen Sulfide Metabolism by Micronutrients, Preliminary Data”
Authors: M. Dattilo, C. Fontanarosa, M. Spinelli, V. Bini and A. Amoresano
Capsule: A dietary supplement is not intended to cure diseases, nevertheless it is fair to demonstrate which is the actual metabolic effect. In the case of Redostim, that introduces a U-turn in metabolic modulation, it was even more important. Volunteers have been tested before and after taking Redostim to evaluate their metaboloma by complex mass spectrometry analyses. The results confirm that Redostim induces H2S.
#Micronutrients, #OneCarbonCycle, #Oocytes, #Blastocyst, #OCM-Checkpoint
Golestanfar 2022 – Doubled Blastocyst Rate
“Metabolic enhancement of the one carbon metabolism (OCM) in bovine oocytes IVM increases the blastocyst rate: evidences for a OCM checkpoint”
Authors: A. Golestanfar, A. Niasari‑Naslaji, F. Jafarpour, S. Rouhollahi, N. Rezaei, Y. Menezo, M. Dattilo & M. H. Nasr‑Esfahani
Capsule: Top paper on top journal investigating the role of OCM support in the maturation and reproductive competence of oocytes. Immature bovine oocytes were cultured and matured in vitro for 24 hours with or without the ingredients of Impryl at a concentration resembling the oral administration in humans. Supported oocytes generated a double number of mature embryos and the effect was entirely due to the improved methylation of maternal DNA (from the support). This demonstrates that only oocytes well fed with micronutrients are able to generate an embryo. To achieve the same results in the clinical setting, we should treat the mothers-to-be while they are maturing the oocytes.
#HydrogenSulfide, #SARS-Cov-2, #Covid 19, #HemeOxygenase1, #CarbonMonoxide
Dattilo 2020 – Host defences in Covid 19
“The role of host defences in Covid 19 and treatments thereof”
Author: M. Dattilo
Capsule: This is a review paper explaining how the virus SARS-CoV2 responsible for Covid 19 achieves virulence by hampering the H2S system. Those with constitutional low H2S reactivity are exposed to a serious disease. Treatments boosting the H2S signalling may be of help in Covid 19. This is already possible by micronutrients.
#ClinicalTrial, #MaleFertility, #Impryl, #Micronutrients
Smits 2020 – Idiopathic male infertility
“Impact of a nutritional supplement (Impryl) on male fertility: study protocol of a multicentre, randomised, double-blind, placebo-controlled clinical trial (SUppleMent Male fERtility, SUMMER trial)”
Authors: R. Smits, K. D’Hauwers, J. IntHout, D. Braat, K. Fleischer
Capsule: This is the official presentation and details disclosure of a huge clinical study with Impryl in male infertility. It is a prospective, randomized, double blind controlled vs placebo clinical trial ongoing at the Radbaud University, The Netherland. The study, started already in 2018, is planned to include 1200 patients to be treated for 6 months and followed-up for 15 months. Originally planned to conclude in December 2023, the study is now expected to take another year to complete the follow-up of treated patients. We are very proud to say that this is the largest and best quality ever study on male infertility.
#Homocysteine, #Micronutrients, #OneCarbonCycle, #PCOS
Schiuma 2020 – Blood homocysteine in PCOS
“Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women”
Authors: N. Schiuma, A. Costantino, T. Bartolotti, M. Dattilo, V. Bini, M. C. Aglietti, M. Renga, A. Favilli, A. Falorni & S. Gerli
Capsule: PCOS women are known for a higher risk of increased homocysteine and this may be related to their fertility problems. Young PCOS women were randomized for supplementation with Impryl or no treatment and their homocysteine was controlled before and after the treatment. Impryl significantly reduced the mean blood homocysteine level. More relevant, all treated patients reduced homocysteine and the average decrease was significant also in the group starting from normal values.
#Metabolism, #Micronutrients, #OneCarbonCycle, #Sperm
Gallo 2018 – Metabolic enhancers affect sperm functionality
“Metabolic enhancers supporting 1-carbon cycle affect sperm functionality: an in vitro comparative study”
Authors: A. Gallo, Y. Menezo, B. Dale, G. Coppola, M. Dattilo, E. Tosti & R. Boni
Capsule: Top paper on top journal investigating the role of OCM support in sperm bioenergetics. Mitochondria produce ROS together with ATP (energy) and can keep on releasing ATP as long as able to neutralize the ROS generated. Human sperm mitochondria where shown to enjoy sustained bioenergetic activity over time when exposed to Impryl micronutrients at the concentration achieved after oral administration.
#WomanFertility, #Micronutrients, #OneCarbonCycle, #OvarianReserve
Silvestris 2017 – One-Carbon Cycle restores ovarian reserve in subfertile women
“Supporting the One-Carbon Cycle restores ovarian reserve in subfertile women: absence of correlation with urinary Bisphenol A concentration”
Authors: E. Silvestris, M. Cohen, D. Cornet, L. Jacquesson-Fournols, P. Clement, J. Chouteau, M. Schneider, T. Besnard, and Y. Ménézo
Capsule: Fifty-five women with a history of 3–7 years of infertility and low AMH level were tested for AMH before and after 4 months of dietary support with micronutrients in support to the OCM. Their AMH value increased independently of the starting value and of age with a mean change from 1.34 to 1.88 (p = 0.0001). Eight patients spontaneously conceived during the 3-months follow-up of the study.
#Sperm, #Oocyte, #OxidativeStress, #DNA, #Methylation, #Epigenetics
Dattilo 2016 – Feeding the antioxidants system improves gamete quality
“Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet”
Authors: M. Dattilo & G. D’Amato & E. Caroppo & Y. Ménézo
Capsule: The role of the OCM in male infertility is reviewed together with the positive effects from a supplementation with methyl donors. These effects appear directly related to the improvement of methylations leading to improved sperm maturation and decreased DNA damage. The rationale for Impryl, coverage of the full pathway and use of pre-activated micronutrients, is explained.